生物医学机器阅读理解（生物医学MRC）旨在理解复杂的生物医学叙事，并协助医疗保健专业人员从中检索信息。现代神经网络的MRC系统的高性能取决于高质量的大规模，人为宣传的培训数据集。在生物医学领域中，创建此类数据集的一个至关重要的挑战是域知识的要求，引起了标记数据的稀缺性以及从标记的通用（源）域转移学习到生物医学（目标）域的需求。然而，由于主题方差，通用和生物医学领域之间的边际分布存在差异。因此，从在通用域上训练的模型到生物医学领域的模型直接转移学会的表示可能会损害模型的性能。我们为生物医学机器阅读理解任务（BioAdapt-MRC）提供了基于对抗性学习的域适应框架，这是一种基于神经网络的方法，可解决一般和生物医学域数据之间边际分布中的差异。 Bioadapt-MRC松弛了生成伪标签的需求，以训练表现出色的生物医学MRC模型。我们通过将生物ADAPT-MRC与三种广泛使用的基准生物医学MRC数据集进行比较，从而广泛评估了生物ADAPT-MRC的性能-Bioasq-7B，BioASQ-8B和BioASQ-9B。我们的结果表明，如果不使用来自生物医学领域的任何合成或人类通知的数据，Bioadapt-MRC可以在这些数据集中实现最先进的性能。可用性：bioadapt-MRC可作为开放源项目免费获得，\ url {https://github.com/mmahbub/bioadapt-mrc}。

ICECUBE是一种用于检测1 GEV和1 PEV之间大气和天体中微子的光学传感器的立方公斤阵列，该阵列已部署1.45 km至2.45 km的南极的冰盖表面以下1.45 km至2.45 km。来自ICE探测器的事件的分类和重建在ICeCube数据分析中起着核心作用。重建和分类事件是一个挑战，这是由于探测器的几何形状，不均匀的散射和冰中光的吸收，并且低于100 GEV的光，每个事件产生的信号光子数量相对较少。为了应对这一挑战，可以将ICECUBE事件表示为点云图形，并将图形神经网络（GNN）作为分类和重建方法。 GNN能够将中微子事件与宇宙射线背景区分开，对不同的中微子事件类型进行分类，并重建沉积的能量，方向和相互作用顶点。基于仿真，我们提供了1-100 GEV能量范围的比较与当前ICECUBE分析中使用的当前最新最大似然技术，包括已知系统不确定性的影响。对于中微子事件分类，与当前的IceCube方法相比，GNN以固定的假阳性速率（FPR）提高了信号效率的18％。另外，GNN在固定信号效率下将FPR的降低超过8（低于半百分比）。对于能源，方向和相互作用顶点的重建，与当前最大似然技术相比，分辨率平均提高了13％-20％。当在GPU上运行时，GNN能够以几乎是2.7 kHz的中位数ICECUBE触发速率的速率处理ICECUBE事件，这打开了在在线搜索瞬态事件中使用低能量中微子的可能性。

The ability to identify and temporally segment finegrained human actions throughout a video is crucial for robotics, surveillance, education, and beyond. Typical approaches decouple this problem by first extracting local spatiotemporal features from video frames and then feeding them into a temporal classifier that captures high-level temporal patterns. We introduce a new class of temporal models, which we call Temporal Convolutional Networks (TCNs), that use a hierarchy of temporal convolutions to perform fine-grained action segmentation or detection. Our Encoder-Decoder TCN uses pooling and upsampling to efficiently capture long-range temporal patterns whereas our Dilated TCN uses dilated convolutions. We show that TCNs are capable of capturing action compositions, segment durations, and long-range dependencies, and are over a magnitude faster to train than competing LSTM-based Recurrent Neural Networks. We apply these models to three challenging fine-grained datasets and show large improvements over the state of the art.

In this paper, we propose a novel technique, namely INVALIDATOR, to automatically assess the correctness of APR-generated patches via semantic and syntactic reasoning. INVALIDATOR reasons about program semantic via program invariants while it also captures program syntax via language semantic learned from large code corpus using the pre-trained language model. Given a buggy program and the developer-patched program, INVALIDATOR infers likely invariants on both programs. Then, INVALIDATOR determines that a APR-generated patch overfits if: (1) it violates correct specifications or (2) maintains errors behaviors of the original buggy program. In case our approach fails to determine an overfitting patch based on invariants, INVALIDATOR utilizes a trained model from labeled patches to assess patch correctness based on program syntax. The benefit of INVALIDATOR is three-fold. First, INVALIDATOR is able to leverage both semantic and syntactic reasoning to enhance its discriminant capability. Second, INVALIDATOR does not require new test cases to be generated but instead only relies on the current test suite and uses invariant inference to generalize the behaviors of a program. Third, INVALIDATOR is fully automated. We have conducted our experiments on a dataset of 885 patches generated on real-world programs in Defects4J. Experiment results show that INVALIDATOR correctly classified 79% overfitting patches, accounting for 23% more overfitting patches being detected by the best baseline. INVALIDATOR also substantially outperforms the best baselines by 14% and 19% in terms of Accuracy and F-Measure, respectively.

When robots learn reward functions using high capacity models that take raw state directly as input, they need to both learn a representation for what matters in the task -- the task ``features" -- as well as how to combine these features into a single objective. If they try to do both at once from input designed to teach the full reward function, it is easy to end up with a representation that contains spurious correlations in the data, which fails to generalize to new settings. Instead, our ultimate goal is to enable robots to identify and isolate the causal features that people actually care about and use when they represent states and behavior. Our idea is that we can tune into this representation by asking users what behaviors they consider similar: behaviors will be similar if the features that matter are similar, even if low-level behavior is different; conversely, behaviors will be different if even one of the features that matter differs. This, in turn, is what enables the robot to disambiguate between what needs to go into the representation versus what is spurious, as well as what aspects of behavior can be compressed together versus not. The notion of learning representations based on similarity has a nice parallel in contrastive learning, a self-supervised representation learning technique that maps visually similar data points to similar embeddings, where similarity is defined by a designer through data augmentation heuristics. By contrast, in order to learn the representations that people use, so we can learn their preferences and objectives, we use their definition of similarity. In simulation as well as in a user study, we show that learning through such similarity queries leads to representations that, while far from perfect, are indeed more generalizable than self-supervised and task-input alternatives.

The latent space of autoencoders has been improved for clustering image data by jointly learning a t-distributed embedding with a clustering algorithm inspired by the neighborhood embedding concept proposed for data visualization. However, multivariate tabular data pose different challenges in representation learning than image data, where traditional machine learning is often superior to deep tabular data learning. In this paper, we address the challenges of learning tabular data in contrast to image data and present a novel Gaussian Cluster Embedding in Autoencoder Latent Space (G-CEALS) algorithm by replacing t-distributions with multivariate Gaussian clusters. Unlike current methods, the proposed approach independently defines the Gaussian embedding and the target cluster distribution to accommodate any clustering algorithm in representation learning. A trained G-CEALS model extracts a quality embedding for unseen test data. Based on the embedding clustering accuracy, the average rank of the proposed G-CEALS method is 1.4 (0.7), which is superior to all eight baseline clustering and cluster embedding methods on seven tabular data sets. This paper shows one of the first algorithms to jointly learn embedding and clustering to improve multivariate tabular data representation in downstream clustering.

An unbiased scene graph generation (SGG) algorithm referred to as Skew Class-balanced Re-weighting (SCR) is proposed for considering the unbiased predicate prediction caused by the long-tailed distribution. The prior works focus mainly on alleviating the deteriorating performances of the minority predicate predictions, showing drastic dropping recall scores, i.e., losing the majority predicate performances. It has not yet correctly analyzed the trade-off between majority and minority predicate performances in the limited SGG datasets. In this paper, to alleviate the issue, the Skew Class-balanced Re-weighting (SCR) loss function is considered for the unbiased SGG models. Leveraged by the skewness of biased predicate predictions, the SCR estimates the target predicate weight coefficient and then re-weights more to the biased predicates for better trading-off between the majority predicates and the minority ones. Extensive experiments conducted on the standard Visual Genome dataset and Open Image V4 \& V6 show the performances and generality of the SCR with the traditional SGG models.

In this paper we discuss the theory used in the design of an open source lightmorphic signatures analysis toolkit (LSAT). In addition to providing a core functionality, the software package enables specific optimizations with its modular and customizable design. To promote its usage and inspire future contributions, LSAT is publicly available. By using a self-supervised neural network and augmented machine learning algorithms, LSAT provides an easy-to-use interface with ample documentation. The experiments demonstrate that LSAT improves the otherwise tedious and error-prone tasks of translating lightmorphic associated data into usable spectrograms, enhanced with parameter tuning and performance analysis. With the provided mathematical functions, LSAT validates the nonlinearity encountered in the data conversion process while ensuring suitability of the forecasting algorithms.

Coronary Computed Tomography Angiography (CCTA) provides information on the presence, extent, and severity of obstructive coronary artery disease. Large-scale clinical studies analyzing CCTA-derived metrics typically require ground-truth validation in the form of high-fidelity 3D intravascular imaging. However, manual rigid alignment of intravascular images to corresponding CCTA images is both time consuming and user-dependent. Moreover, intravascular modalities suffer from several non-rigid motion-induced distortions arising from distortions in the imaging catheter path. To address these issues, we here present a semi-automatic segmentation-based framework for both rigid and non-rigid matching of intravascular images to CCTA images. We formulate the problem in terms of finding the optimal \emph{virtual catheter path} that samples the CCTA data to recapitulate the coronary artery morphology found in the intravascular image. We validate our co-registration framework on a cohort of $n=40$ patients using bifurcation landmarks as ground truth for longitudinal and rotational registration. Our results indicate that our non-rigid registration significantly outperforms other co-registration approaches for luminal bifurcation alignment in both longitudinal (mean mismatch: 3.3 frames) and rotational directions (mean mismatch: 28.6 degrees). By providing a differentiable framework for automatic multi-modal intravascular data fusion, our developed co-registration modules significantly reduces the manual effort required to conduct large-scale multi-modal clinical studies while also providing a solid foundation for the development of machine learning-based co-registration approaches.

Detecting abrupt changes in data distribution is one of the most significant tasks in streaming data analysis. Although many unsupervised Change-Point Detection (CPD) methods have been proposed recently to identify those changes, they still suffer from missing subtle changes, poor scalability, or/and sensitive to noise points. To meet these challenges, we are the first to generalise the CPD problem as a special case of the Change-Interval Detection (CID) problem. Then we propose a CID method, named iCID, based on a recent Isolation Distributional Kernel (IDK). iCID identifies the change interval if there is a high dissimilarity score between two non-homogeneous temporal adjacent intervals. The data-dependent property and finite feature map of IDK enabled iCID to efficiently identify various types of change points in data streams with the tolerance of noise points. Moreover, the proposed online and offline versions of iCID have the ability to optimise key parameter settings. The effectiveness and efficiency of iCID have been systematically verified on both synthetic and real-world datasets.